Coimbatore houses a large number of small and medium textile mills. It also has a central textile research institutes like the Central Institute for Cotton Research (CICR) - Southern Regional station and the Sardar Vallabhai Patel International School of Textiles and Management.

The South Indian Textiles Research Association (SITRA) is also based in Coimbatore. The city also houses two of the Centers of Excellences (COE) for technical textiles proposed by Government of India, namely Meditech, a medical textile research centre based at SITRA, and InduTech based in PSG College of Engineering and Technology.

Coimbatore has an extensive and a diversified manufacturing sector facilitated by the presence of research institutes like Tamil Nadu Agricultural University, South India Textile Research Association (SITRA) and large number of engineering colleges producing about 50,000 engineers yearly.

Some of the prominent industries in Coimbatore include L&T, BOSCH, PSG, Sakthi group, Lakshmi Machine Works (LMW), Premier Instruments & Control Limited (PRICOL), Premier Evolvics, Janatics, LGB, Revathi Equipment Ltd, ELGI Equipments, Craftsman Automation Pvt Ltd, Shanthi Gears, Roots Industries.

Coimbatore has more than 700 wet grinder manufacturers with a monthly output of about 75,000 units (as of March 2015) per every 100,000 produced in India. The term "Coimbatore Wet Grinder" was given a Geographical indication for wet grinders manufactured since 2005-06. The wet grinder manufacturing industry provides direct employment to more than 20,000 people and 50,000 people are benefitted indirectly.

It is also referred as the “Pump city of Asia”. The City houses large number of small scale engineering companies. The motor and pump industry supplies two third of India’s requirements, while its wet- grinder industry has a near monopoly. The Major Pump industries Sharp Industries, CRI Pumps, Texmo Industries, Deccan Pumps & KSB Pumps are renowned worldwide owing to its qualitative output.

The size of the Coimbatore health care industry has been estimated as 1500 Crore (150 million) in 2010. There are nearly 750 hospitals in and around Coimbatore with a capacity of 5000 beds. Our Coimbatore Municipal Corporation is also running 20 Urban Health Posts (UHP) and they provide services free of cost to the public, which is a welcome one. 5 AIDS control centres are also functioning. In terms of dispensaries, there are 11 Allopathic, 3 Ayurvedic, and 2 Siddha dispensaries which are proud of serving the common men.

)The first health care center in the city was started in 1909. In 1969, it was upgraded to Coimbatore Medical College Hospital (CMCH). It is a government run hospital with bed strength of 1020 and provides free health care. The city also has many large multi-facility private hospitals like the PSG Hospitals, Kovai Medical Center and Hospital (KMCH), KG Hospital, Coimbatore Kidney Centre, G. Kuppuswamy Naidu Memorial Hospital, Sri Ramakrishna Hospital, Sheela Hospital, Kongunad Hospital, Gem Hospital, Ganga Hospital, Aravind Eye Hospital, Sankara Netralaya, Lotus Eye Hospital, Ashwin hospital, Vikram ENT hospital, Coimbatore Cancer Foundation, G.P.Hospital etc.